Accurate results
for patient care
Laboratory medicine and in vitro diagnostics
JCTLM Database: higher-order reference materials, methods and services
Details : C11RMP8 - Roche method for quantification of acetaminophen in human serum by LC-MS/MS
| Type (acronym) | rmp |
|---|---|
| Type | reference measurement procedure |
| Unique Nomination Number | C11RMP8 |
| Analyte Name | acetaminophen |
| IUPAC IFCC Number | CAS 103-90-2 |
| Method capable of Traceability of Analyte to SI or Defined Procedure | SI |
| Applicable Matrices | human EDTA plasma, human Li Heparin plasma, human serum (gel free tubes only); each fresh or frozen |
| Name | Roche method for quantification of acetaminophen in human serum by LC-MS/MS |
| Organization that developed Validated Method | Roche Diagnostics GmbH |
| Measurement Techniques Used | LC/MS/MS |
| Comments 1 | acetaminophen-d3 as internal standard |
| Comments 2 | Calibrate with USP Acetaminophen (Lot K01244) |
| Quantity | Mass concentration |
| From (0) | 0.05 |
| To (0) | 100 |
| Unit (0) | mg/l |
| Level of Confidence (%) | 95% |
| Peer Reviewed Publication | Simultaneous quantification of acetaminophen and structurally related compounds in human serum and plasma, Bylda C et al., Drug Test Anal., 2014, 6(5), 451-460 |
| Comments to be published via JCTLM DB | The reference measurement procedure, C11 RMP8, for quantification of acetaminophen in human serum was developed and validated by Roche Diagnostics GmbH. |
| Review Team Name | Drugs |
| Analyte Category Name | Drugs |
| Non-CCQM Key Comparison Report | Transfer of measurement procedure to Labor Limbach, Heidelberg, Germany and conducting method comparison using 32 patient plus 24 spiked serum samples |
| Non-CCQM Key Comparison Report Hyperlink | |
| Measurement principle/technique | Liquid chromatography mass spectrometry |