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Details : C11RMP9 - Mass spectrometry-based candidate reference measurement procedure for quantification of Aβ42 in cerebrospinal fluid
| Type (acronym) | rmp |
|---|---|
| Type | reference measurement procedure |
| Unique Nomination Number | C11RMP9 |
| Analyte Name | amyloid beta 1-42 |
| IUPAC IFCC Number | Amyloid Beta 1-42 |
| Method capable of Traceability of Analyte to SI or Defined Procedure | SI |
| Applicable Matrices | human cerebrospinal fluid |
| Name | Mass spectrometry-based candidate reference measurement procedure for quantification of Aβ42 in cerebrospinal fluid |
| Organization that developed Validated Method | Roche Diagnostics GmbH in collaboration with the University of Gothenburg |
| Measurement Techniques Used | Isotope dilution mass spectrometry |
| Comments 1 | 13C-labelled Aß42 as internal standard |
| Comments 2 | draft version of manuscript attached |
| Quantity | Mass concentration |
| From (0) | 150 |
| To (0) | 4000 |
| Unit (0) | pg/ml |
| From (1) | 15.7 |
| To (1) | 15.7 |
| Unit (1) | % |
| Level of Confidence (%) | 95% |
| Peer Reviewed Publication | Clin. Chem., 2014, 60(7), 987-994 Mass spectrometry-based candidate reference measurement procedure for quantification of Aβ42 in cerebrospinal fluid, A. Leinenbach et al. on behalf of the IFCC Scientific Division Working Group on CSF proteins (WG-CSF) |
| Comments to be published via JCTLM DB | The reference measurement procedure, C11 RMP9, for quantification of Aβ42 in cerebrospinal fluid was developed and validated by Roche Diagnostics GmbH in collaboration with the University of Gothenburg |
| Review Team Name | proteins |
| Analyte Category Name | Proteins |
| Non-CCQM Key Comparison Report | See reference cited above for comparability assessment study |
| Measurement principle/technique | Isotope dilution mass spectrometry |