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Details : C13RMP1 - Quantification of Gentamicin by LC-MS/MS
| Type (acronym) | rmp |
|---|---|
| Type | reference measurement procedure |
| Unique Nomination Number | C13RMP1 |
| Analyte Name | gentamicin |
| IUPAC IFCC Number | CAS1403-66-3 |
| Method capable of Traceability of Analyte to SI or Defined Procedure | SI |
| Applicable Matrices | fresh, or frozen human blood serum or human blood plasma |
| Name | Quantification of Gentamicin by LC-MS/MS |
| Organization that developed Validated Method | Roche Diagnostics GmbH in collaboration with the Institute of Laboratory Medicine, Hospital of the University of Munich |
| Measurement Techniques Used | LC-MS/MS |
| Comments 1 | gentamicin-glycine derivatives as internal standard |
| Comments 2 | Calibrate with USP Gentamcin Sulfate (Lot M1J001) |
| Quantity | Mass concentration |
| Level of Confidence (%) | 95% |
| Peer Reviewed Publication | An LC-MS/MS based candidate reference method for the quantification of total gentamicin in human serum and plasma using NMR characterized calibrator material, Lucha S et al., Clinica Chimica Acta, 2017, 464, 211-217 |
| Comments to be published via JCTLM DB | The reference measurement procedure, C13 RMP1, for quantification of gentamicin in human serum or plasma was developed and validated by Roche Diagnostics GmbH in collaboration with the Institute of Laboratory Medicine, Hospital of the University of Munich |
| Analyte Category Name | Drugs |
| Non-CCQM Key Comparison Report | See reference cited above for comparability assessment study |
| Non-CCQM Key Comparison Report Hyperlink | |
| Measurement principle/technique | Liquid chromatography mass spectrometry |