Accurate results
for patient care
Laboratory medicine and in vitro diagnostics
JCTLM Database: higher-order reference materials, methods and services
Details : C14RMP5 - LC-MS/MS based candidate reference method for the quantification of carbamazepine in human serum
| Type (acronym) | rmp |
|---|---|
| Type | reference measurement procedure |
| Unique Nomination Number | C14RMP5 |
| Analyte Name | carbamazepine |
| IUPAC IFCC Number | CAS298-46-4 |
| Method capable of Traceability of Analyte to SI or Defined Procedure | SI |
| Applicable Matrices | fresh or frozen human serum |
| Name | LC-MS/MS based candidate reference method for the quantification of carbamazepine in human serum |
| Organization that developed Validated Method | Roche Diagnostics GmbH in collaboration with the Labormedizinisches Zentrum Dr Risch Anstalt |
| Measurement Techniques Used | Liquid Chromatography Mass Spectrometry (LC-MS/MS) |
| Comments 1 | as primary calibration material an ISO certified reference material was used |
| Comments 2 | carbamazepine-10,11-epoxide and 10-hydroxy-10,11-dihydrocarbamazepine were additionally monitored |
| Quantity | Mass concentration |
| From (0) | 0.1 |
| To (0) | 22 |
| Unit (0) | µg/ml |
| Level of Confidence (%) | 95% |
| Peer Reviewed Publication | An LC-MS/MS based candidate reference method for the quantification of carbamazepine in human serum, Taibon J. et al, Clinica Chimica Acta, 2017, 475, 35-40 |
| Hyperlink to Final Report of extent of Equivalence Studies among | The reference measurement method, C14 RMP5, for the quantification of carbamazepine in human serum was developed and validated by Roche Diagnostics GmbH in collaboration with the Labormedizinisches Zentrum Dr Risch Anstalt. |
| Analyte Category Name | Drugs |
| Non-CCQM Key Comparison Report | See reference cited above for comparability assessment study |
| Non-CCQM Key Comparison Report Hyperlink | |
| Measurement principle/technique | Liquid chromatography mass spectrometry |