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Details : C15RM2 - Aβ 1-42 in CSF
| Type (acronym) | rm2 |
|---|---|
| Type | reference material |
| Unique Nomination Number | C15RM2 |
| Analyte Name | Amyloid beta peptide (1-42) |
| IUPAC IFCC Number | amyloid beta |
| List I, II or III | List I |
| Basis for Traceability Claim | SI |
| Applicable Matrices | liquid frozen human cerebrospinal fluid (CSF) |
| Identifier Number | ERM-DA481/IFCC |
| Name | Aβ 1-42 in CSF |
| Certifying Organization | JRC |
| Quantity | Mass concentration |
| From (0) | 0.72 |
| To (0) | 0.72 |
| Unit (0) | µg/L |
| From (1) | 0.11 |
| To (1) | 0.11 |
| Unit (1) | µg/L |
| Level of Confidence (%) | 95 % |
| Reference to Commutability Study Publication | Commutability of the certified reference materials for the standardization of β-amyloid 1-42 assay in human cerebrospinal fluid: lessons for tau and β-amyloid 1-40 measurements, Andreasson et al., Clinical Chemistry and Laboratory Medicine, 2018, 56(12), 2058-2066 Assessing the commutability of reference material formats for the harmonization of amyloid-ß measurements, Bjerke et al., Clinical Chemistry and Laboratory Medicine, 2016, 54(7), 1177-1191 |
| Other Relevant Publications | CSF Abeta 1-42 an excellent but complicated Alzheimer's biomarker: a route for standardisation, Kuhlmannet al., Clinica chimica acta, 2017, 467(7), 27-33 |
| Comments 1 | Each sample consists of at least 0.5 mL of liquid frozen human cerebrospinal fluid (CSF) |
| Organization Acronym | EU - JRC |
| Organization Name | European Commission - Joint Research Centre |
| Organization Website | https://crm.jrc.ec.europa.eu/ |
| Organization Country ISO Code | BE |
| Organization Country Name | Belgium |
| Analyte Category Name | Proteins |