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Details : C19RMP1 - NCCL ID LC-MS/MS reference measurement procedure for cortisol
| Type (acronym) | rmp |
|---|---|
| Type | reference measurement procedure |
| Unique Nomination Number | C19RMP1 |
| Analyte Name | Cortisol |
| IUPAC IFCC Number | CAS50-23-7 |
| Method capable of Traceability of Analyte to SI or Defined Procedure | Traceable to SI |
| Applicable Matrices | human serum; fresh, frozen or lyophilized |
| Name | NCCL ID LC-MS/MS reference measurement procedure for cortisol |
| Organization that developed Validated Method | National Center for Clinical Laboratories (NCCL) |
| Measurement Techniques Used | Isotope dilution mass spectrometry, liquid chromatography mass spectrometry |
| Quantity | Amount-of-substance concentration |
| From (0) | 30 |
| To (0) | 2500 |
| Unit (0) | nmol/L |
| From (1) | 1.5 |
| To (1) | 1.5 |
| Unit (1) | % |
| Level of Confidence (%) | 95 % |
| Peer Reviewed Publication | Development and validation of a candidate reference method for serum cortisol by isotope dilution liquid chromatography-tandem mass spectrometry combined with dextran sulfate-Mg2+ precipitation, Zhang T. et al, Analytical and Bioanalytical Chemistry 2020 412(6):1325-1333 |
| Additional Comments | No |
| Hyperlink to Final Report of extent of Equivalence Studies among | C19RMP1-Extent-of-equivalence_Report_Cortisol.pdf |
| Analyte Category Name | Non-peptide hormones |
| Non-CCQM Key Comparison Report | See IFCC EQAS RELA results in 2016, 2018 and 2021 (lab code 18) |
| Non-CCQM Key Comparison Report Hyperlink | http://www.dgkl-rfb.de:81/ |
| Measurement principle/technique | Isotope dilution mass spectrometry |