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Details : C19RMP2 - ID-LC-MS/MS-based reference measurement procedure for quantification of aldosterone in human serum and plasma
| Type (acronym) | rmp |
|---|---|
| Type | reference measurement procedure |
| Unique Nomination Number | C19RMP2 |
| Analyte Name | aldosterone |
| IUPAC IFCC Number | CAS52-39-1 |
| Method capable of Traceability of Analyte to SI or Defined Procedure | yes |
| Applicable Matrices | human serum and plasma; fresh or frozen |
| Name | ID-LC-MS/MS-based reference measurement procedure for quantification of aldosterone in human serum and plasma |
| Organization that developed Validated Method | This reference measurement procedure was developed and validated by Roche Diagnostics GmbH in Penzberg, Germany in collaboration with the Universitätsklinikum Erlangen, Klinik für Kinder und Jugendliche, Erlangen, Germany |
| Measurement Techniques Used | Isotope dilution mass spectrometry |
| Quantity | Mass concentration |
| From (0) | 20 |
| To (0) | 1200 |
| Unit (0) | pg/ml |
| From (1) | 2.4 |
| To (1) | 3 |
| Unit (1) | % |
| Level of Confidence (%) | 0.95 |
| Comments on Uncertainty Range | The expected measurement uncertainty of 2.4 % is at the mass concentration of 60.0 pg/mL, where n = 6 measurements. The expected measurement uncertainty of 3.0 % is at the mass concentration of 1000.0 pg/mL, where n = 6 measurements. |
| Peer Reviewed Publication | An isotope dilution-liquid chromatography-tandem mass spectrometry (ID-LC-MS/MS)-based candidate reference measurement procedure (RMP) for the quantification of aldosterone in human serum and plasma. Taibon J. et al, Clinical Chemisty and Laboratory Medicine 2023 61(11) 1902-1916 |
| Comments to be published via JCTLM DB | This reference measurement procedure was developed and validated by Roche Diagnostics GmbH in Penzberg, Germany in collaboration with the Universitätsklinikum Erlangen, Klinik für Kinder und Jugendliche, Erlangen, Germany |
| Analyte Category Name | Non-peptide hormones |
| Non-CCQM Key Comparison Report | Trueness was assessed using the certified secondary reference material from the National Metrology Institute of Japan (NMIJ, CRM 6402-b) as well as leftover samples from the RELA Scheme from the years 2016 and 2018 and two samples with reference values (93.9 and 437 ng/mL) provided by the Reference Institute of Bioanalytics (RfB). In addition a method comparison study was performed in cooperation with the Universitätsklinikum Erlangen, Klinik für Kinder und Jugendliche . |
| Non-CCQM Key Comparison Report | See IFCC-RELA resuts for Lab 163 |
| Measurement principle/technique | Isotope dilution mass spectrometry |