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Details : C20RMP11 - ID-LC-MS/MS-based reference measurement procedure for the quantification of primidone in human serum and plasma
| Type (acronym) | rmp |
|---|---|
| Type | reference measurement procedure |
| Unique Nomination Number | C20RMP11 |
| Analyte Name | primidone |
| IUPAC IFCC Number | CAS125-33-7 |
| Method capable of Traceability of Analyte to SI or Defined Procedure | yes |
| Applicable Matrices | human serum and plasma; fresh or frozen |
| Name | ID-LC-MS/MS-based reference measurement procedure for the quantification of primidone in human serum and plasma |
| Organization that developed Validated Method | This reference measurement procedure was developed and validated by the laboratory of Dr. Risch Ostschweiz AG in Buchs SG, Switzerland in collaboration with Roche Diagnostics GmbH in Penzberg, Germany |
| Measurement Techniques Used | Isotope dilution mass spectrometry |
| Quantity | Mass concentration |
| From (0) | 0.15 |
| To (0) | 30 |
| Unit (0) | µg/mL |
| From (1) | 2 |
| To (1) | 1.8 |
| Unit (1) | % |
| Level of Confidence (%) | 0.95 |
| Comments on Uncertainty Range | The expected measurement uncertainty of 2.0 % is at the mass concentration of 0.200 µg/mL, where n = 6, sample preparations. The expected measurement uncertainty of 1.8 % is at the mass concentration of 25.0 µg/mL, where n = 6, sample preparations. |
| Peer Reviewed Publication | An isotope dilution-liquid chromatography-tandem mass spectrometry (ID-LC-MS/MS)-based candidate reference measurement procedure (RMP) for the quantification of primidone in human serum and plasma, Taibon J. et al, Clinical Chemisty and Laboratory Medicine 2024 62(7) 1327-1338 |
| Comments to be published via JCTLM DB | This reference measurement procedure was developed and validated by the laboratory of Dr. Risch Ostschweiz AG in Buchs SG, Switzerland in collaboration with Roche Diagnostics GmbH in Penzberg, Germany |
| Analyte Category Name | Drugs |
| Measurement principle/technique | Isotope dilution mass spectrometry |