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Details : C21RMP9 - NIST reference method for urine albumin
| Type (acronym) | rmp |
|---|---|
| Type | reference measurement procedure |
| Unique Nomination Number | C21RMP9 |
| Analyte Name | albumin (ALB) |
| IUPAC IFCC Number | CAS9006-50-2 |
| Method capable of Traceability of Analyte to SI or Defined Procedure | SI |
| Applicable Matrices | human urine; fresh or frozen |
| Name | NIST reference method for urine albumin |
| Organization that developed Validated Method | National Institute of Standards and Technology (NIST) |
| Measurement Techniques Used | Isotope Dilution-Liquid Chromatography-Tandem Mass Spectrometry (ID-LC-MS/MS) |
| Quantity | Mass concentration |
| From (0) | 5 |
| To (0) | 500 |
| Unit (0) | mg/L |
| From (1) | 13.5 |
| To (1) | 8.6 |
| Unit (1) | % |
| Level of Confidence (%) | 95% |
| Peer Reviewed Publication | 1. Multiplexed LC-MS/MS assay for urine albumin Beasley-Green A et al, J. Proteome Res. 2014 13(9) 3930-3939 2. Estimation of measurement uncertainty for the quantification of protein by LC-MS/MS Beasley-Green A et al, Anal. Bioanal. Chem. 2023 415 3265-3274 3. Reference measurement procedure for the absolute quantification of albumin in urine using Isotope Dilution-Liquid Chromatography-Tandem Mass Spectrometry (ID-LC-MS/MS) Beasley-Green A et al, NIST Special Publication 1200-31 2024 |
| Additional Comments | [mailto:ashley.beasley@nist.gov ashley.beasley@nist.gov] |
| Analyte Category Name | Proteins |
| Non-CCQM Key Comparison Report | Miller G et al, Clin. Chem. 2024 70(11) 1375-1382 |
| Non-CCQM Key Comparison Report Hyperlink | https://doi.org/10.1093/clinchem/hvae122 Clin |
| Non-CCQM Key Comparison Report | Extent of equivalence of results for urine albumin among 3 candidate mass spectrometry reference measurement procedures |
| Measurement principle/technique | Isotope dilution mass spectrometry |
| Measurement principle/technique | High performance liquid chromatography |